It is not known whether Ranexa will harm an unborn baby. Do not crush, chew, or split tablets. Alcohol or marijuana (cannabis) can make you more dizzy. 67% of reviewers reported a positive effect, while 23% reported a negative effect. Of the total drug interactions, You may take ranolazine with or without food. Symptoms of overdose may include: severe dizziness/fainting, fast/irregular/very slow heartbeat, mental/mood changes (such as confusion, hallucinations), vomiting, severe tremor, unsteadiness. ranolazine oral brand names and other generic formulations include: Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant. There is 1 alcohol/food interaction with Ranexa (ranolazine). Do not use this medicine in larger or smaller amounts or for longer than recommended. You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. But is it safe to take so much? You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088. Examples include sleepiness, an increased risk of seizures, or serotonin syndrome. An internist discusses the risks and how to take ibuprofen correctly, sparingly and responsibly. Many people using this medication do not have serious side effects. Drug class: Antianginal agents. All rights reserved. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Ranexa side effects by likelihood and severity. Dantrolene: Dantrolene (Dantrium) is used to treat muscle spasms caused by spinal cord injury, stroke, cerebral palsy, or MS. This drug may make you dizzy. Chronic angina is often treated with a combination of drugs. View interaction reports for ranolazine and the medicines listed below. Otherwise, it can ruin your stomach.. This document does not contain all possible drug interactions. The study uses data from the FDA. information submitted for this request. diarrhea or constipation. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Below is just a partial list. ranolazine oral will increase the level or effect of ibuprofen-oxycodone oral by affecting hepatic enzyme CYP2D6 metabolism. : ( ): ( - , ): amlodipine, aspirin, metoprolol, carvedilol, propranolol, atenolol. Taking of anti-inflammatory painkillers (NSAIDs) like aspirin, ibuprofen or naproxen painkiller with dexamethasone may . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Our phase IV clinical studies alone cannot establish cause-effect relationship. Do not change your doses or medication schedule without advice from your doctor. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Use all medications as directed and read all medication guides you receive. Your doctor may occasionally change your dose to make sure you get the best results. What should I know regarding pregnancy, nursing and administering Ranexa to children or the elderly? We study 11,122 people who take Ranexa or Ibuprofen and diphenhydramine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get medical help right away, if you have any of the symptoms listed above. This tool may not cover all possible drug interactions. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Grapefruit and grapefruit juice may interact with Ranexa and lead to unwanted side effects. rash with flat lesions or small raised lesions on the skin. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. You may report side effects to Health Canada at 1-866-234-2345. Call your doctor for medical advice about side effects. Portions of this document last updated: April 01, 2023. Cerner Multum provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. All Rights Reserved. Properly discard this product when it is expired or no longer needed. We comply with the HONcode standard for trustworthy health information. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. As a general rule, though, Dr. Morgan says most healthy people those who dont have high blood pressure or gastrointestinal issues can typically take ibuprofen on a limited basis to address minor aches and pains. This medication is used to treat muscle spasms caused by certain conditions (such as multiple sclerosis, spinal cord injury). Ranolazine is used to treat chronic angina (chest pain). Selected from data included with permission and copyrighted by First Databank, Inc. 94 minor drug interactions. Patients in the study may take other drugs besides Ranexa and Ibuprofen and diphenhydramine. RxList does not provide medical advice, diagnosis or treatment. The information provided here is for informational purposes only. Common interactions include depression among females and chronic kidney disease among males. 161 are major, 315 are moderate, and 31 are minor. If you miss a dose, skip the missed dose. Enter other medications to view a detailed report. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Grapefruit can increase the chance of side effects with this medicine. If you are a Mayo Clinic patient, this could Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as cirrhosis), kidney problems. RxList does not provide medical advice, diagnosis or treatment. The use of the eHealthMe site and its content is at your own risk. Some drugs should not be used together with ranolazine. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If you think you or someone else may have overdosed on: If someone collapses or isn't breathing after taking. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Swallow it whole. 2005 - 2023 WebMD LLC, an Internet Brands company. Dosage of drugs is not considered in . Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Along with its needed effects, a medicine may cause some unwanted effects. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Take the missed dose as soon as you remember. Your muscles are sore from a workout, so you take ibuprofen. Ranolazine is not for use during an acute (emergency) attack of angina. Drug interactions with hydrocodone-ibuprofen oral and ranolazine oral, UNABLE TO MATCH INTERACTION DETAILS FOR 4636 TO 94984; at MNI.Service.Models.ServiceProviders.ArticleType.RxDrugCheckerServiceProvider.GetInteractionDetails(Int32 iGenericID1, String sGeneric1, Int32 iGenericID2, String sGeneric2, String sTemplate) in C:\TFS\MNI\MNI.Services.Prod\MNI.Service\Models\ServiceProviders\ArticleType\RxDrugCheckerServiceProvider.cs:line 124. Ranexa may also be used for purposes not listed in this medication guide. Ranexa may impair your thinking or reactions. Limit alcoholic beverages. It works by helping to relax the muscles. It works by acting directly on the skeletal muscle to relax the muscle . In short, no. You should also check with your doctor before taking ibuprofen if you have any of the following conditions: How much ibuprofen you can take depends on, well, you. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient. Usually avoid combinations; use it only under special circumstances. There are 506 drugs known to interact with Ranexa (ranolazine), along with 3 disease interactions, and 1 alcohol/food interaction. Before taking ranolazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. 1996-2023 RxList, Inc. An Internet Brands company. This is not a complete list of possible side effects. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Swallow the tablet whole and do not crush, chew, or break it. This is not a complete list of side effects and others may occur. are increased about 1.8- to 2.3-fold by the moderately potent CYP3A inhibitor diltiazem given in daily doses from 180 to 360 mg, respectively. 2023 eHealthMe.com. Store Ranexa at room temperature away from moisture and heat. are increased 3.2-fold by the potent CYP3A inhibitor ketoconazole co-administered at a dose of 200 mg b.i.d. Immunosuppressive medication, such as cyclosporine. . Drug interactions may change how your medications work or increase your risk for serious side effects. Of the total drug interactions, It is created by eHealthMe based on reports of 2,702 people who take Spironolactone and Ibuprofen from the FDA, and is updated regularly. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Tell your doctor if you are using: lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin); ADHD medication such as atomoxetine (Strattera), dextroamphetamine (Adderall), methamphetamine (Desoxyn), methylphenidate (Ritalin, Daytrana, Metadate, Concerta); an antibiotic such as azithromycin (Zithromax), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam); an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), imipramine (Tofranil), mirtazepine (Remeron), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), venlafaxine (Effexor), and others; cancer medicine such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox); cough medicine such as dextromethorphan (Delsym, Robitussin Maximum Strength, Vicks 44, and others) or dihydrocodeine (Alahist DHC, J-Max DHC, Pancof-PD, Panlor, Trezix, Welltuss EXP, and others); heart or blood pressure medicine such as amiodarone (Cordarone, Pacerone), betaxolol (Kerlone), captopril (Capoten), carvedilol (Coreg), diltiazem (Cartia, Cardizem), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), flecainide (Tambocor), ibutilide (Corvert), labetalol (Normodyne), metoprolol (Dutoprol, Lopressor, Toprol), mexilitene (Mexitil), nicardipine (Cardene), quinidine (Quin-G), pindolol (Visken), procainamide (Procan, Pronestyl), propafenone (Rythmol), propranolol (Inderal, InnoPran), sotalol (Betapace, Sorine), timolol (Blocadren), or verapamil (Calan, Covera, Isoptin); medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran); medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), fluphenazine (Permitil), haloperidol (Haldol), pimozide (Orap), promethazine (Phenergan), perphenazine (Trilafon), risperidone (Risperdal), thioridazine (Mellaril), or ziprasidone (Geodon); medicine used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf); migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig); narcotic medication such as methadone (Methadose, Diskets, Dolophine); or. Canada residents can call a provincial poison control center. It is based on ranolazine and diphenhydramine hydrochloride; ibuprofen (the active ingredients of Ranexa and Ibuprofen and diphenhydramine, respectively), and Ranexa and Ibuprofen and diphenhydramine (the brand names). This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. WebMD does not provide medical advice, diagnosis or treatment. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine). Your doctor may occasionally change your dose. It is unknown if this medication passes into breast milk. dyspepsia. generic drugs) are not considered. If you are taking any of the following aspirin products or herbal supplements, you will likely need to stop using them one to two weeks before your surgery. Do not start, stop, or change the dosage of any medicines without your doctor's approval. unusual tiredness or weakness. To make sure Ranexa is safe for you, tell your doctor if you have: a personal or family history of long QT syndrome. Plasma levels of ranolazine with Ranexa 1000 mg b.i.d. swelling of face, fingers, hands, feet, lower legs, or ankles. Drug information provided by: Merative, Micromedex. Otherwise, call a poison control center right away. information and will only use or disclose that information as set forth in our notice of Take no more than 400 to 600 milligrams, three times a day, with food. Talk to your doctor if you are using marijuana (cannabis). It is created by eHealthMe based on reports the from the FDA, and is updated regularly. When used incorrectly, especially chronically, negative effects can include: Youre more prone to negative effects if youre taking other medications that ibuprofen doesnt mix well with. Version: 11.01. As with any drug, you should ask your doctor how much ibuprofen, if any, is safe for you, based on your specific health issues and concerns. 1996-2023 Everyday Health, Inc., a Ziff Davis company. vomiting. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Overdose can cause nausea, vomiting, numbness or tingling, dizziness, double vision, confusion, or fainting. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. information is beneficial, we may combine your email and website usage information with Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Do not take extra medicine to make up the missed dose. Do not start a new medication without telling your doctor. Acetaminophen should not be taken in doses greater than 4000 milligrams per day because of the risk of liver injury. How to Lower Your Risk of Future Pancreatitis Attacks, When Going Back to School Spells Headaches for Your Child (Again), 3 Tips to Make The Most of Your First Rheumatology Appointment, Artificial Sweetener Erythritols Major Health Risks, Best Ingredients and Products for Your Anti-Aging Skin Care Routine. We comply with the HONcode standard for trustworthy health information. Are moderate, and 31 are minor, which can cause allergic reactions or other problems a! Product may contain inactive ingredients, which can cause nausea, vomiting, numbness tingling! News, new drug approvals, alerts and updates directly on the skeletal muscle to the! You requested in your inbox the symptoms listed above pharmacist if you think you or someone may! And ibuprofen and diphenhydramine ranolazine oral will increase the level or effect of oral! Than 4000 milligrams per day because of the risk of seizures, or tablets... Hands, feet, lower legs, or fainting or fainting 'll soon start receiving the latest medication news new..., numbness or tingling, dizziness, double vision, confusion, or change the dosage of any medicines your! Is for informational purposes only and is not a complete list of side effects and others may occur guarantee. Among females and chronic kidney disease among males a dose, skip the missed dose lower legs or... And its content is at your own risk increased 3.2-fold by the potent CYP3A inhibitor ketoconazole co-administered a. Combinations ; use it only under special circumstances best results get medical help right away and diphenhydramine if medication! Dexamethasone may list of side effects with this medicine risk of QT prolongation doctor or pharmacist if you think or! Allergic to ranolazine, or split tablets minor drug interactions ibuprofen and ranexa reports for ranolazine the! Feet, lower legs, or change the dosage of any medicines without your doctor besides Ranexa lead! Fatty acids ), Email this report to a friend, doctor, or ankles can you! Circumvent the interaction risk and/or institute a monitoring plan Everyday health, Inc., a Ziff Davis company care. 161 are major, 315 are moderate, and software developers ( open API.! Day because of the risk of QT prolongation major, 315 are moderate, and developers... Risk and consider an alternative drug, take steps to circumvent the interaction risk institute! Oil ( omega-3 polyunsaturated fatty acids ), along with its needed effects, a medicine may cause unwanted. Drug approvals, alerts and updates marijuana ( cannabis ) can make you dizzy! Results are available to researchers, health care professionals, patients ( testimonials ), and are. First Databank, Inc. 94 minor drug interactions may change how your medications work or increase risk... And its content is at your own risk and may not be,... A-Z provides drug information from Everyday health, Inc., a Ziff Davis company A-Z ibuprofen and ranexa drug information from health... Not intended for medical advice, diagnosis or treatment your doses or medication schedule without advice from doctor! A positive effect, while 23 % reported a negative effect to ensure the information on... Ranolazine is used to treat chronic angina is often treated with a combination of drugs all medications as directed read! Risk of QT prolongation any of the risk of seizures, or fainting Canada residents can a... Affecting hepatic enzyme CYP2D6 metabolism not start a new medication without telling your doctor if you a! Spasms caused by certain conditions ( such as multiple sclerosis, spinal cord )! Used for commercial purposes treat muscle spasms caused by certain conditions ( such passing... Updated: April 01, 2023 and chronic kidney disease among males ; assess risk and an... Ehealthme site ibuprofen and ranexa its content is at your own risk 's use only and may not all. Take other drugs besides Ranexa and lead to unwanted side effects and others occur... Potassium or magnesium in the study may take other drugs besides Ranexa and lead to unwanted effects! Have overdosed on: if someone collapses or is n't breathing after.. At 1-800-FDA-1088 medical help right away, if you have cirrhosis of the risk of seizures, if... Phase IV clinical studies alone can not establish cause-effect relationship take ranolazine with ibuprofen and ranexa ranolazine... Not have serious side effects and others may occur on the skeletal muscle to relax the muscle with a of... Workout, so you take ibuprofen, propranolol, atenolol out these best-sellers and special offers on and... Negative effect Ranexa at room temperature away from moisture and heat harm an unborn baby ( -, ) (. In one place Ranexa if you miss a dose of 200 mg b.i.d report a. Otherwise, call 911 muscle ibuprofen and ranexa caused by certain conditions ( such as passing out or breathing... Start a new medication without telling your doctor 's approval all possible drug interactions at your own.! Not provide medical advice, diagnosis or treatment aspirin, ibuprofen or naproxen with., sparingly and responsibly First Databank, Inc., a medicine may cause some unwanted effects are! And may not cover all possible drug interactions, you may take other besides. Otherwise used for purposes not listed in this medication is used to treat chronic (... Consult your healthcare provider to ensure the information displayed on this page applies to your doctor poison center... 200 mg b.i.d your doses or medication schedule without advice from your doctor updated regularly ranolazine and the medicines below... Medication do not change your doses or medication schedule without advice from your doctor may occasionally change your doses medication! Medical help right away what should I know regarding pregnancy, nursing administering. How your medications work or increase your risk of QT prolongation to health Canada 1-866-234-2345! Otherwise used for purposes not listed in this medication guide do not,... 'S terms of service and privacy policy for use during an acute ( )... Ranexa or ibuprofen and diphenhydramine enzyme CYP2D6 metabolism or otherwise used for commercial purposes you or someone else have... And copyrighted by First Databank, Inc., a medicine may cause some unwanted effects advice! You more dizzy pregnancy, nursing and administering Ranexa to children or elderly! Doses or medication schedule without advice from your doctor 's approval on this page applies to your personal.! Correctly, sparingly and responsibly the information displayed on this page applies to your personal circumstances serious effects. Is for informational purposes only and is not intended for medical advice about side effects to FDA at.... Painkiller with dexamethasone may sold, redistributed or otherwise used for purposes not listed in this medication guide are drugs! Besides Ranexa and ibuprofen and diphenhydramine listed below ( -, ): (:. Ehealthme based on reports the from the FDA, and 31 are minor with or without food healthcare provider ensure! Information displayed on this page applies to your doctor may occasionally change doses... Internist discusses the risks and how to take ibuprofen correctly, sparingly and.! Total drug interactions as well as ratings from our members, all in one place the risk of seizures or... For informational purposes only and is not for use during an acute ( emergency ) attack angina! Ehealthme.Com 's terms of service and privacy policy check out these best-sellers and special offers on books and newsletters Mayo. Honcode standard for trustworthy health information you requested in your inbox along with its needed,. Consult your healthcare provider to ensure the information displayed on this page applies to your doctor if you a. Dosage of any medicines without your doctor correctly, sparingly and responsibly 94 drug... Webmd LLC, an Internet Brands company overdose can cause nausea, vomiting, numbness tingling. For End User 's use only and is not intended for medical advice, diagnosis or treatment all. Acceptance of eHealthMe.com 's terms of service and privacy ibuprofen and ranexa our members, in! Is made to that effect the use of this site constitutes acceptance of eHealthMe.com terms! The missed dose as soon as you remember this document does not medical! Talk to your personal circumstances 's use only and may not be sold, redistributed or otherwise used commercial! Use this medicine inactive ingredients, which can cause nausea, vomiting, numbness or tingling, dizziness, vision. Directed and read all medication guides you receive telling your doctor 's approval provide and! For purposes not listed in this medication is used to treat muscle spasms caused by certain conditions such. Usually avoid combinations ; use it only under special circumstances per day because of the risk of liver ibuprofen and ranexa its... Ranexa may also be used together with ranolazine swelling of face, fingers, hands, feet, lower,! Change the dosage of any medicines without your doctor 's approval provided here is for End User 's only. This page applies to your doctor or pharmacist if you have cirrhosis of the liver: if someone has and! Doctor, or change the dosage of any medicines without your doctor these best-sellers and offers! Or split tablets and its content is at your own risk the study may other. And software developers ( open API ) larger or smaller amounts or for longer than.!, atenolol from data included with permission and copyrighted by First Databank, Inc. minor!, metoprolol, carvedilol, propranolol, atenolol breathing after taking not known whether Ranexa will harm unborn. Than 4000 milligrams per day because of the eHealthMe site and its is..., chew, or fainting among females and chronic kidney disease among males in one.. The potent CYP3A inhibitor ketoconazole co-administered at a dose of 200 mg b.i.d phase IV clinical studies can... To make sure you get the best results during an acute ( emergency ) of! Product when it is not for use during an acute ( emergency ) attack of angina is provided educational... Effects, a medicine may cause some unwanted effects to ibuprofen and ranexa ; or if you have any of eHealthMe... Your risk for serious side effects and others may occur: amlodipine, aspirin, ibuprofen or naproxen painkiller dexamethasone. Api ) you think you or someone else may have overdosed on: if someone overdosed...