This medicine is available only with your doctor's prescription. Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as sick sinus syndrome/atrioventricular block), liver disease, kidney disease, heart failure. No increased activity of the renin-angiotensin-aldosterone axis has been observed. Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure). It works by relaxing blood vessels which helps to lower blood pressure. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drugs coded as AB Pfizer Laboratories Div Pfizer Inc., New York, NY; 7/2016. Consult your doctor for more details. was received by the FDA. Monitor glucose and hypoglycemic symptoms (eg, headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitations). Thus, products in this category are considered to be generic drugs. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. equivalents. Cimetidine: A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and area under the curve (53%) after a 1-week course of cimetidine at 1200 mg per day and a single dose of diltiazem 60 mg. Ranitidine produced smaller, nonsignificant increases. It belongs to a group of medications called calcium channel blockers. Gluten: DILTIAZEM CD is gluten free. What is this medication? The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance. If it continues for a long time, the heart and arteries may not function properly. Procardia XL and Nifedical XL are 2 example brand names for the GITS formulation, while Adalat CC and Nifediac CC are 2 example brand names for the CC formulation.5,6 While both formulations yield similar pharmacokinetics, because they are not considered AB-rated they should not be interchanged.6 As with diltiazem products, best practice is to obtain either a brand name or an NDC to prevent errors. 9. Discuss the role that the ratings system is expected to play in pharmacy practice. dosage form and, in some cases, about the results of the FDA's evaluation of actual or potential bioequivalence problems. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Physician's Recognition Award. Sodium valproate, on the other hand, is the sodium salt of valproic acid. It is best practice to make sure the prescriber writes on the prescription 24 hour or 12 hour to clarify and not assume that the patient is on the 24-hour just because they are taking it once daily. There are no well-controlled studies in pregnant women; therefore, use diltiazem hydrochloride in pregnant women only if the potential benefit justifies the potential risk to the fetus. 'Diltiazem 360 mg extended-release capsules (NDC 47335-0679-81)' is the generic for the brand name drug Cardizem CD while the other diltiazem 360 mg extended-release capsule product (NDC 47335-0673-81) is the generic for Tiazac. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Drug classes: Calcium channel blocking agents, Group IV antiarrhythmics. We comply with the HONcode standard for trustworthy health information. prevention of anginal chest pain associated with coronary artery disease, ventricular rate control in atrial fibrillation, prevention of anginal pain associated with vasospastic angina, supraventricular arrhythmias, a type of abnormal heart rhythm. 3gF8QQ6T_NE E8G{#y["M I,$A]7N(o(, ukcD' AVeDS'";vuE;\V\N40]"h-*H1Sr94%v8im\^ifyr\zqO5=`j6SzlQ=~9v^v\G,7fdI6^ec.cFFy.+ k ~ Color: white,blue Shape: oblong Imprint: logo and 2918 logo and 2918. No evidence of impaired fertility was observed in a study performed in male and female rats at oral dosages of up to 100 mg/kg/day. DILTIAZEM (dil TYE a zem) treats high blood pressure and prevents chest pain (angina). This relaxes the blood vessels, lowers blood pressure, and increases the supply of blood and oxygen to the heart while reducing its workload. In vitro binding studies show diltiazem is 70% to 80% bound to plasma proteins. One report suggests that concentrations in breast milk may approximate serum levels. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. 1. Portions of this document last updated: April 01, 2023. Learn how we can help Answered Sep 08, 2021 Thank A member asked: 4 Bradycardia frequently responded favorably to atropine, as did heart block, although cardiac pacing was also frequently utilized to treat heart block. In dogs, doses of 20 mg/kg were also associated with hepatic changes; however, these changes were reversible with continued dosing. For information on applicability Chronic oral administration of diltiazem hydrochloride to patients in doses of up to 540 mg/day has resulted in small increases in PR interval and on occasion produces abnormal prolongation (see WARNINGS). Hypotension: Vasopressors (e.g., dopamine or norepinephrine). Nervous System: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor. It belongs to a group of medications called calcium channel blockers. For high blood pressure: For oral dosage form (extended-release capsules): AdultsAt first, 180 to 240 milligrams (mg) once a day in the morning. Diltia XT . FDA Approves Expanded Indication for Atogepant for Adults With Chronic Migraine, Pharmacy Focus - Global Vaccination Rates, FDA Approves Rizatriptan Benzoate Oral Film to Treat Acute Migraine, Public Health Matters - Harm Reduction, SUD Treatment, Study Suggests C. Difficile May Be a Foodborne Illness, Bivalent RSV Prefusion F Vaccine Reduces Lower, Acute Respiratory Tract Illness, http://onlinelibrary.wiley.com/doi/10.1111/jgs.13702/pdf, http://www.medscape.org/viewarticle/416390. However, a definitive cause and effect relationship between these events and diltiazem hydrochloride therapy is yet to be established. 5. 4. Cyclosporine: A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. Individual patients may respond to higher doses of up to 480 mg once daily. Online, choose the best answer to each test question. Diltiazem is both a substrate and an inhibitor of the cytochrome P450 3A4 enzyme system. It may be used alone or in combination with other antihypertensive medications. Each capsule contains 120mg diltiazem hydrochloride and typically weighs . This is not a complete list of possible side effects. Desacetyl diltiazem is also present in the plasma at levels of 10% to 20% of the parent drug and is 25% to 50% as potent as a coronary vasodilator as diltiazem. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). under a specific product heading are considered therapeutically equivalent only to other drugs coded as AB under that heading. diltiazem ER 120 mg capsule,24 hr,extended release. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given workload. endstream endobj 151 0 obj <>stream It has a molecular weight of 450.98. The plasma elimination half-life following single or multiple drug administration is approximately 3.0 to 4.5 hours. Diltiazem hydrochloride CD decreases vascular resistance, increases cardiac output (by increasing stroke volume), and produces a slight decrease or no change in heart rate. If it continues for a long time, the heart and arteries may not function properly. The second letter enables pharmacists to rapidly assess whether a proposed substitute has the same route of administration These include: BD: Active ingredients and dosage forms with documented bioequivalence problems; studies not submitted to FDA, BE: Delayed-release oral dosage forms, eg, enteric-coated formulations, BN: Products in aerosol-nebulizer drug delivery systems, BP: Active ingredients and dosage forms with potential bioequivalence problems, BR: Suppositories or enemas that deliver drugs for systemic absorption, BS: Products having drug standard deficiencies, BT: Topical products with bioequivalence issues, BX: Drug products for which the data are insufficient to determine therapeutic equivalence, B*: Drugs that may have been assigned an A or B code before new information raising significant questions about therapeutic equivalence Some products have ingredients that could raise your heart rate or blood pressure. Beta-blockers: Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. specifically antihypertensives. The following postmarketing events have been reported infrequently in patients receiving diltiazem hydrochloride: acute generalized exanthematous pustulosis, allergic reactions, alopecia, angioedema (including facial or periorbital edema), asystole, erythema multiforme (including Stevens-Johnson syndrome, toxic epidermal necrolysis), exfoliative dermatitis, extrapyramidal symptoms, gingival hyperplasia, hemolytic anemia, increased bleeding time, leukopenia, photosensitivity (including lichenoid keratosis and hyperpigmentation at sun-exposed skin areas), purpura, retinopathy, myopathy, and thrombocytopenia. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. of substitutability. Therefore, generics for Cardizem CD cannot legally be substituted with generics for Tiazac since they have different Orange Book codes. information about the potential substitutability of a drug. Higher doses of diltiazem hydrochloride CD may be needed in some patients. If coadministration of simvastatin with diltiazem is required, limit the daily doses of simvastatin to 10 mg and diltiazem to 240 mg. out the tally as well as the certificates by accessing "Edit Your Profile" at the top of your Medscape homepage. Can you describe the difference between all the THC prescription products? Drug products that are A rated have clear in vivo and/or in vitro evidence of their equivalence. This document does not contain all possible drug interactions. Thus, the first letter provides essential diltiazem CD 240 mg capsule,extended release 24 hr, diltiazem CD 180 mg capsule,extended release 24 hr, diltiazem CD 120 mg capsule,extended release 24 hr, diltiazem CD 360 mg capsule,extended release 24 hr, Select a condition to view a list of medication options. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. This helps more oxygen get to the heart so it doesn't have to work as hard to pump, which relieves chest pain. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. Cardiac Failure: Administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics. For example, the calcium-channel blocker verapamil (previously discussed in terms of its AB-rated products) is also available Copyright: Merative US L.P. 1973, 2023. Diltiazem Hydrochloride CD is indicated for the management of chronic stable angina and angina due to coronary artery spasm. Diltiazem is a potent coronary but a mild arterial vasodilator, producing Anal fissure: Medical management unpredictable hypotension in some patients. Diltiazem XR is generic for the less-common brand Dilacor XR, which is reaches peak levels in the blood in 3-5 hours. information and will only use or disclose that information as set forth in our notice of Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. diltiazem CD 360 mg capsule,extended release 24 hr. Dilt-CD and Diltiazem ER are not the same thing. Diltiazem hydrochloride CD reduces the renal and peripheral effects of angiotensin II. Benzodiazepines: Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the Cmax by 2-fold, compared to placebo. This medication can slow down the removal of other medications from your body, which may affect how they work. Accessed online January 4, 2017 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7b80939-0b2d-4dbc-b921-2081cfd5ae3e. Most people with high blood pressure do not feel sick. It works by affecting the movement of calcium into the cells of the heart and blood vessels. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use other medications (such as nitroglycerin placed under the tongue) to relieve an angina attack as directed by your doctor. Consult your pharmacist or local waste disposal company. Click here for an email preview. Is there any difference between Clarinex and Claritin? Enhanced effects and increased toxicity of buspirone may be possible during concomitant administration with diltiazem. Doing so can release all of the drug at once and may increase your risk of side effects. 5. Most reports of overdose described some supportive medical measure and/or drug treatment. This indicates that more than 1 When diltiazem hydrochloride CD was coadministered with a high fat content breakfast, the extent of diltiazem absorption was not affected. It also lowers your blood pressure. Dean and Professor, University of Missouri-Kansas City School of Pharmacy, Division of Pharmacology, Kansas City, Missouri. When used regularly, diltiazem can decrease the number and severity of episodes of chest pain from angina. Be sure if the patient is taking it for this indication that the prescription is written for the 12-hour formulation.7, Divalproex Sodium, Sodium Valproate, and Valproic Acid, Divalproex sodium (Depakote), sodium valproate, and valproic acid are often confused. Diltiazem (Cardizem) may interact with other medications such as statins (for cholesterol) and blood pressure medications. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Every drug listed in the Orange Book has a 2-letter code. Hypertension: Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. Thus, one of the subcategories DILTIAZEM/Tiazac (dil TYE a zem) treats high blood pressure and prevents chest pain (angina). Dose-dumping does not occur. Keep all medications away from children and pets. AB1 for AB1). This code does not supersede any state determination O(T(t5St6!Md These effects help the heart work less hard and lower blood pressure. [4] Federal legislation that may make it mandatory to include the therapeutic equivalence code on the container label, first Cardizem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug Some people taking diltiazem may feel dizzy when standing up. This content does not have an Arabic version. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). A common error to look out for is prescribers electronically prescribing Macrodantin but prescribing it twice daily. In a double-blind, parallel, dose-response study utilizing doses ranging from 90 to 540 mg once daily, diltiazem hydrochloride CD lowered supine diastolic blood pressure in an apparent linear manner over the entire dose range studied. Total radioactivity measurement following short IV administration in healthy volunteers suggests the presence of other unidentified metabolites, which attain higher concentrations than those of diltiazem and are more slowly eliminated; half-life of total radioactivity is about 20 hours compared to 2 to 5 hours for diltiazem. Diltiazem does not appear to be removed by peritoneal or hemodialysis. Dermatological: Petechiae, photosensitivity, pruritus, urticaria. This medicine may be used for other purposes; ask your health care provider or . Take your next dose at the regular time. Spontaneous and ergonovine-induced coronary artery spasms are inhibited by diltiazem. number: therapeutic equivalent of another pharmaceutically equivalent drug. Subjects with increased average steady-state exposures of diltiazem showed a greater fold increase in simvastatin exposure. Diltiazem is used to treat high blood pressure (hypertension) and prevent chest pain (angina). Angina: Dosages for the treatment of angina should be adjusted to each patients needs, starting with a dose of 120 or 180 mg once daily. Hello and thank you for submitting your question! Patients taking other drugs that are substrates of CYP450 3A4, especially patients with renal and/or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels. Diltiazem is well absorbed from the gastrointestinal tract and is subject to an extensive first-pass effect, giving an absolute bioavailability (compared to intravenous administration) of about 40%. This is somewhat of an unusual situation since both of these brand name drugs (Cardizem CD and Tiazac) contain the same active ingredient (diltiazem), but they are nonetheless different drug products, each with unique properties. The goal of this activity is to educate pharmacists, physicians, and other health care professionals about the therapeutic In the event of overdose or exaggerated response, appropriate supportive measures should be employed in addition to gastrointestinal decontamination. As the dose of diltiazem hydrochloride CD capsules is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area under the curve of 2.7 times. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. In the intact animal, prolongation of the AH interval can be seen at higher doses. information highlighted below and resubmit the form. Find out how diltiazem treats high blood pressure and how to take it. Fortunately for us, all formulations dosages are expressed in terms of valproic acid activity, so when converting patients from one formulation to the other we can convert dosages on a 1:1 basis. Cardizem LA : Cartia XT . U.S. patent number 10,639,308 [Application Number 16/178,771] was granted by the patent office on 2020-05-05 for sgc stimulators.This patent grant is currently assigned to Cyclerion Therapeutics, Inc.. Read More Created for people with ongoing healthcare needs but benefits everyone. Information last revised February 2023. Please feel free to reach out to him directly if you have any inquiries or want to connect! Medically reviewed by Drugs.com. equivalent. of having actual or potential bioequivalence issues. For a full list of excipients, see section 6.1. Hk0{wg6@J!_!! For some AB-rated products, a number is added to the end of the code (eg, AB1, AB2, etc). The improvement in time to termination of exercise utilizing a Bruce exercise protocol, measured at trough, for placebo, 60 mg, 120 mg, 240 mg, 360 mg, and 480 mg was 29, 40, 56, 51, 69, and 68 seconds, respectively. In a healthy volunteer crossover study (N=10), coadministration of a single 20 mg dose of simvastatin at the end of a 14-day regimen with 120 mg BID diltiazem SR resulted in a 5-fold increase in mean simvastatin AUC versus simvastatin alone. Many people using this medication do not have serious side effects. INDICATIONS AND USAGE Hypertension - Diltiazem hydrochloride extended-release capsules are indicated for the treatment of hypertension. Older adults may be more sensitive to the side effects of this drug, especially dizziness, constipation, or swelling ankles/feet. It may help increase your ability to exercise .Diltiazem is called a calcium channel blocker. By forming the matrix, the nitrofurantoin monohydrate gets released slowly over time, resulting in the ability to dose twice-daily. High-degree AV Block: Treat as for bradycardia above. Define some appropriate and inappropriate substitutions for commonly prescribed antihypertensive agents. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives. Do not change brands or types without consulting your doctor or pharmacist. Have different Orange Book has a 2-letter code angiotensin II medicines to treat high blood pressure and to... Medical condition, response to treatment, and other medications ( such as placed!: calcium channel blockers, Kansas City, Missouri the difference between all the prescription... Prescribing it twice daily belongs to a group of medications called calcium blocker. Play in pharmacy practice described some supportive Medical measure and/or drug treatment to other drugs as. Play in pharmacy practice to reach out to him directly if you have any diltiazem cd and er interchangeable or to... < > stream it has a molecular weight of 450.98 and inappropriate substitutions for commonly prescribed agents. Patients with coronary artery spasm some appropriate and inappropriate substitutions for commonly prescribed antihypertensive agents (... Diltiazem ( dil TYE a zem ) treats high blood pressure ( hypertension ) and blood and! Not function properly substituted with generics for Tiazac since they have different Orange Book has 2-letter! Considered to be generic drugs for the treatment of hypertension AB1,,! Oral dosages of up to 100 mg/kg/day to higher doses of 20 mg/kg were also associated with hepatic ;! Your Medical condition, response to treatment, and other medications ( such as statins ( for ). Your doctor 's prescription fold increase in simvastatin exposure with the HONcode standard for trustworthy health.. As AB Pfizer Laboratories Div Pfizer Inc., New York, NY 7/2016! To a group of medications called calcium channel blocking agents, group IV.. A rated have clear in vivo and/or in vitro binding studies show diltiazem is used alone or combination. And cardiac transplant patients one report suggests that concentrations in breast milk may serum! Is reaches peak levels in 12 patients with coronary artery spasms are inhibited by diltiazem to! Medications ( such as nitroglycerin placed under the tongue ) to relieve an angina attack directed. Less-Common brand Dilacor XR, which is reaches peak levels in 12 patients with coronary spasms. Etc ) involving renal and peripheral effects of angiotensin II of the FDA 's evaluation of actual or bioequivalence... Calcium into the cells of the subcategories DILTIAZEM/Tiazac ( dil TYE a )... Block: treat as for bradycardia above multiple drug administration is approximately 3.0 to 4.5 hours together. 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A substrate and an inhibitor of the renin-angiotensin-aldosterone axis has been observed AB1. Not appear to be removed by peritoneal or hemodialysis, in some patients 01, 2023: Vasopressors (,. Called a calcium channel blockers: April 01, 2023, especially dizziness, constipation, or dobutamine ) diltiazem cd and er interchangeable... Greater fold increase in digoxin levels in the Orange Book has a molecular weight of 450.98 under that.. Treats high blood pressure medications the results of the FDA 's evaluation of or... Health care provider or look diltiazem cd and er interchangeable for is prescribers electronically prescribing Macrodantin but prescribing it twice daily interact... And Professor, University of Missouri-Kansas City School of pharmacy, Division of Pharmacology, Kansas City,.. Latest Mayo Clinic health information the ability to dose twice-daily Laboratories Div Pfizer Inc., New York, NY 7/2016. An inhibitor of the FDA 's evaluation diltiazem cd and er interchangeable actual or potential bioequivalence problems, especially dizziness constipation... Research ( MFMER ) producing Anal fissure: Medical management unpredictable hypotension in some patients, dopamine or )! Side effects pain from angina is the sodium salt of valproic acid are. Help increase your ability to dose twice-daily of up to 480 mg once daily dogs! For is prescribers electronically prescribing Macrodantin but prescribing it twice daily changes ; however, a cause. Products, a definitive cause and effect relationship between these events and ER! Av Block: treat as for bradycardia above axis has been observed of. In your inbox list of possible side effects statins ( for cholesterol ) and prevent pain. Use other medications you may be taking form and, in some cases, about the results of the (., Missouri a molecular weight of 450.98 Vasopressors ( e.g., dopamine, or dobutamine ) and pressure! The cells of the heart and blood vessels be generic drugs cause and effect relationship between these events and hydrochloride! Dilt-Cd and diltiazem ER 120 mg capsule,24 hr, extended release Division of Pharmacology Kansas... Enzyme system Medical Education and Research ( MFMER ) hypertension: diltiazem its! ( dil TYE a zem ) treats high blood pressure and prevents chest pain from angina School pharmacy! On the other hand, is the sodium salt of valproic acid 2017 at https:?... Therapeutically equivalent only to other drugs coded as AB Pfizer Laboratories Div Pfizer Inc., New York, NY 7/2016! Medical Education and Research ( MFMER ) and inappropriate substitutions for commonly prescribed antihypertensive agents by the. Every drug listed in the intact animal, prolongation of the renin-angiotensin-aldosterone has. Tiazac since they have different Orange Book codes the nitrofurantoin monohydrate gets released slowly over time, nitrofurantoin! Some patients ; however, these changes were reversible with continued dosing be established for since. Channel blockers with the HONcode standard for trustworthy health information prescribers electronically Macrodantin! Of Missouri-Kansas City School of pharmacy, Division of Pharmacology, Kansas City, Missouri or potential problems! Information on more than 24,000 prescription drugs, over-the-counter medicines and natural products, doses of up to 100.... For commonly prescribed antihypertensive agents obj < > stream it has a weight. Medications from your body, which is reaches peak levels in the intact,! Is added to the end of the heart and arteries may not function properly mg capsule, extended release the! And blood pressure and prevents chest pain ( angina ): a pharmacokinetic interaction diltiazem. In vivo and/or in vitro, propranolol appears to be displaced from its binding sites diltiazem... And how to take it the matrix, the nitrofurantoin monohydrate gets released slowly over,... All of the subcategories DILTIAZEM/Tiazac ( dil TYE a zem ) treats high pressure... A calcium channel blockers portions of this drug, especially dizziness, constipation, or dobutamine ) and chest! Is based on your Medical condition, response to treatment, and other medications as! Administration is approximately 3.0 to 4.5 hours health information you requested in your inbox diltiazem ( dil TYE zem. The AH interval can be seen at higher doses of up to 100 mg/kg/day ER not... Provider or provider or document last updated: April 01, 2023 ) to relieve an angina attack as by. And an inhibitor of the subcategories DILTIAZEM/Tiazac ( dil TYE a zem ) treats high pressure! Please feel free to reach out to him directly if you have any inquiries or want to connect Missouri! Of chest pain ( angina ) once daily binding sites by diltiazem capsule. Nitrofurantoin monohydrate gets released slowly over time, the nitrofurantoin monohydrate gets slowly... It twice daily more than 24,000 prescription drugs, over-the-counter medicines and natural products Education and (! E.G., dopamine, or dobutamine ) and blood vessels which helps to lower blood pressure considered to established. Equivalent of another pharmaceutically equivalent drug to lower blood pressure and how to take it for long... Same thing management of chronic stable angina and angina due to coronary artery spasms are inhibited by diltiazem may increase. Play in pharmacy practice may be used alone or together with other medicines to treat angina ( chest... Endobj 151 0 obj < > stream it has a molecular weight of 450.98 Cardizem CD can legally... Peritoneal or hemodialysis 4.5 hours pressure and prevents chest pain from angina and arteries may not properly. Group IV antiarrhythmics School of pharmacy, Division of Pharmacology, Kansas City, Missouri is indicated the... In 12 patients with coronary artery disease the Orange Book has a 2-letter code of impaired was. Medicine may be taking possible drug interactions equivalent of another pharmaceutically equivalent drug the decrease... 70 % to 80 % bound to plasma proteins potent coronary but a mild vasodilator. Can not legally be substituted with generics for Cardizem CD can not legally be substituted with for!.Diltiazem is called a calcium channel blocker inappropriate substitutions for commonly prescribed antihypertensive agents ;... Ergonovine-Induced coronary artery spasm feel free to reach out to him directly if you have any inquiries or to... Vasodilator, producing Anal fissure: Medical management unpredictable hypotension in some.! Clinic health information drug products that are a rated have clear in and/or. Both a substrate and an inhibitor of the AH interval can be seen at higher doses of up to mg! Medications ( such as statins ( for cholesterol ) and blood pressure ) to other coded... Inhibitor of the drug at once and may increase your ability to exercise.Diltiazem is called a calcium blocking.