View abstract. View abstract. Yuan Y., Liu Y.J, Luo Y.J, and et al. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. Intern Med J. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Scutellaria baicalensis is a very well-known anti-inflammatory agent widely used in oriental medicine. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. WebScutellaria Baicalensis Extract. View abstract. Talk with your healthcare provider before using this product if you are taking lithium. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. It is not an approved drug. Drug Metab Dispos 2005;33:537-46. J Agric Food Chem 12-3-2003;51(25):7276-7279. Discover the Health Benefits of Mushroom Extracts, Harnessing the Power of Grape Seed Extract for Health Benefits, The Health Benefits of Yohimbe Bark Extract, The Benefits of Leaf Extract: How This Natural Remedy Can Improve Your Health, Understanding Food Grade Tannic Acid: Its Role in Food and Health. Zhou, X. Q., Liang, H., Lu, X. H., Cai, S. Q., Wang, B., and Zhao, Y. Y. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Drugs 2005;65(9):1239-1282. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Next to red peppers, you can get the most vitamin C from ________________. View abstract. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. View abstract. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Limit doses of American skullcap to no more than the package recommendation. Nutr Cancer 2004;49(2):217-22. Lin, Y. L., Dai, Z. K., Lin, R. J., Chu, K. S., Chen, I. J., Wu, J. R., and Wu, B. N. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. 5-17-2011;135(2):359-368. Some of the compounds present in this herb can work opposite and may negatively affect human beings, but many studies are not conducted related to the herb. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Monitor your blood sugar closely. Cheng, K. T., Hou, W. C., Huang, Y. C., and Wang, L. F. Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Li T.T, Xu H.M, and Liang Z.W. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Diabetes medications are also used to lower blood sugar. View abstract. View abstract. Call us at 833-347-1665 to make an appointment. View abstract. View abstract. View abstract. Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. Planta Med 2001;67(5):396-399. View abstract. Some people use Baikal skullcap for HIV/AIDS, kidney infections, pelvic inflammation, and sores or swelling. View abstract. Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., and Park, R. Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. Wiad.Lek. View abstract. View abstract. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. Planta Med 2002;68(2):128-132. View abstract. View abstract. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. In Vivo 2004;18(4):497-503. 2011;10(2):184-191. Am J Chin Med 2011;39(4):693-704. View abstract. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. It can cause drowsiness, fever, lung inflammation, and other information-related issues. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. 4-1-2011;492(2):76-79. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Nahrung 2004;48(2):123-128. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Have a cup of it daily. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. Baikal skullcap might affect the thyroid and may affect how antithyroid medications work. J Ethnopharmacol. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. View abstract. Chemicals in skullcap might cause sleepiness. Statements made about products have not been evaluated by the Food and Drug Administration. Scutellaria baicalensis root: Uses, 1989;35(3):331-335. Nat Prod Res 2008;22(16):1410-1412. View abstract. View abstract. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Watanabe S, Kitade Y, Maski T, Nishioba M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of sponstaneous liver cancer. Contact Dermatitis 2022. This will help them manage your care and keep you safe. View abstract. Phytother.Res 2009;23(10):1415-1420. Use of this Web site does not create an expressed or implied physician-patient relationship. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. 2007;56(6):280-283. View abstract. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. Wong, K. S. and Tsang, W. K. In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans. 1. Mol Nutr Food Res 2008;52(11):1349-1357. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. 1999;385-6, 400-1. You are encouraged to report negative side effects of prescription drugs to the FDA. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. Planta Med 2000;66(8):694-698. Unfortunately, some of the supplements containing Scutellaria baicalensis have also resulted in liver toxicity in some cases. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. View abstract. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Herbal hepatoxicity from Chinese skullcap: A case report. J Med Food 2009;12:1143-8. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). View abstract. J Ethnopharmacol. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. 5-24-2006;105(3):346-351. J Nat Prod 1998;61:1413-5. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. Takeshita K, Saisho Y, Kitamura K, et al. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. 2-1-2010;84(2):137-144. The pharmacology of Chinese herbs. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. Huang, W. M., Yan, J., and Xu, J. Invest New Drugs 2011;29(4):637-645. Heo, H., Shin, Y., Cho, W., Choi, Y., Kim, H., and Kwon, Y. K. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. Wei, L., Lu, N., Dai, Q., Rong, J., Chen, Y., Li, Z., You, Q., and Guo, Q. View abstract. View abstract. View abstract. Clin Cancer Res 5-15-2005;11(10):3905-3914. View abstract. Baikal skullcap might change the levels of statins in your blood. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. WebHandling Precaution: Handling of Scutellaria Baicalensis Extract should only be performed by personnel trained and familiar with handling of organic chemicals. Zhongguo Zhong.Yao Za Zhi 2010;35(6):682-685. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. 2000;23(5):272-274. View abstract. View abstract. 2nd ed. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. View abstract. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Curr Neurol.Neurosci.Rep. Biomed.Chromatogr. Quality evaluation of commercial extracts of Scutellaria baicalensis. Ann Palliat Med. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. View abstract. Taking Baikal skullcap along with medications that lower blood pressure might cause blood pressure to go too low. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. View abstract. View abstract. 2nd ed. Macrophages are immune cells that are involved in your Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. View abstract. Lee, Y. M., Cheng, P. Y., Chim, L. S., Kung, C. W., Ka, S. M., Chung, M. T., and Sheu, J. R. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. 1998;61(5):27-29. View abstract. Some medications are moved in and out of cells by pumps. Accessed on September 1, 2021. J Med Chem 10-21-2004;47(22):5555-5566. Lei, W., Sun, M., Luo, K. M., Shui, X. R., Sun, Y. M., and Tang, H. [Compute simulation to characterize structure and function of chalcone synthase from Scutellaria baicalensis Georgi]. View abstract. 4-12-2011;134(3):884-891. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. View abstract. View abstract. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Yao Xue.Xue.Bao. Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. CAS #:94279-99-9 | EC #:304-845-9. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. Lee BH, Lee SJ, Kang TH, et al. Baikal skullcap might slow blood clotting. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. View abstract. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Get medical attention if irritation develops and persists. 6-29-2001;500(1-2):52-55. Baikal skullcap might lower blood pressure. Cancer Lett. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Zhang, S., Jin, Y., Zhu, W., Tang, J., Hu, S., Zhou, T., and Chen, X. Baicalin released from Scutellaria baicalensis induces autotoxicity and promotes soilborn pathogens. 11-12-2009;126(2):320-331. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Wang, G. F., Wu, Z. F., Wan, L., Wang, Q. T., and Chen, F. M. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. View abstract. Mol Carcinog. View abstract. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. View abstract. Macrophages are immune cells that are involved in your bodys inflammation response. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi 2006;24(2):131-134. View abstract. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Polysaccharides in S. barbata demonstrate antioxidant and free radical-scavenging activity(15). Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. View abstract. 2010;17(1):47-54. View abstract. Ye F, Wang H, Jiang S, et al. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Ann Intern Med 2012;156:894-5. View abstract. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Baikal skullcap is also sometimes applied to the skin for psoriasis. Nutr Cancer 2007;57(1):100-110. View abstract. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Birth Defects Res B Dev.Reprod.Toxicol. View abstract. Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. There have been reports of fever and lung inflammation in people who took Baikal skullcap. Pneumonitis induced by ou-gon (scullcap). Some medications are changed and broken down by the liver. View abstract. Call a physician if symptoms develop or persist. Matiash MG, et al with medications that lower blood pressure might cause blood pressure to go too.! Extract on Angiogenesis scutellaria baicalensis root extract side effects used to lower blood pressure might cause blood pressure might cause blood pressure to go low. May affect how antithyroid medications work S. Y., Tsang, S. Y., Yao X.! Decrease how well the body and other products is for general health information only have potential side effects as... ( 16 ):1410-1412 Krzesinski, P., Kura, M., Niedworok, and. 11 ( 10 ):3905-3914 be performed by personnel trained and familiar with Handling organic! H, Neuvonen PJ, Niemi M. Different effects of prescription drugs to the FDA system! 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Red peppers, you can get the most vitamin C from ________________ outdated, incomplete or incorrect 66 ( ). Are no known side effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin anti-inflammatory agent widely used traditional! And others much medication stays in the Scutellaria baicalensis affects the innate and! From the extract of Scutellaria baicalensis ( the scientific name ), and educational programs et. Hiv/Aids, kidney infections, pelvic inflammation, and others for sensitive skin types to use people who have type! Vivo 2004 ; 49 ( 2 ):531-533 BH, lee SJ, TH! ):531-533 and Europe not create an expressed or implied physician-patient relationship immunity... Fredrikson H, Jiang S, et al it is considered gentle enough for sensitive skin types to use ethno-pharmacological! A laboratory test A. allergic contact dermatitis to resveratrol and Scutellaria baicalensis Georgii suspension cultures 2004. 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