I would probably try something like Advantix II or Frontline Gold before Vectra. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the . 2022 Collie Chatter. This can be orally administered to the dogs, which are safe and remain effective for one full month. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. I like Frank so much that I had to give him his own story. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. We have an 11 year old tricolor rough coat collie. The login page will open in a new tab. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. Theyre so fun and crazy at that age. Much appreciated! I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. Another one that still seems to be working good is afoxolaner (Nexgard). I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. Thank you again for all your help : ). In summary, use with caution. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Thanks. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Our dogs deserve the best. My vet wants to give him a vaccine (?) A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. enough to have 4 dogs like I do! I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. . The vet is really no help. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. Is Simparica Safe For Dogs? But it doesnt hurt mammals. The vet thought he would be nice and put Advantage Multi on our cats. I was using Seresto collars and am on the hunt for something else. Will you be updating this article with regard to Seresto? No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Enjoy your girl! I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Unacceptable for me) He is MDR1 clear. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. (MDR1 -/-) following single oral administration at 5 times the . Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Personalizing your pets health care. The manufacturer's website provides this warning This is so thorough and helpful! Please log in again. Should I give them Trifexis or Sentinel Spectrum? Simparica (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. But frankly we're baffled that they've approved it. Did your research find anything about using Seresto collar for just short periods of time? However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Both of those products should definitely be more effective than the Frontline Plus. Happy to be of help! Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Thanks for reply. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. Sugar is a great name for a Collie as they really are such sweethearts. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Isoxazolines are potent inhibitors of gamma-aminobutyric acid (GABA)- and glutamate-gated chloride channels in the nervous system of invertebrates [ 3 ]. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Hi. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. It was both well written, and concise. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Ive changed the label on the Seresto section and added some info to keep it current. What an awesome article. Additionally, it can also be given to cats and even pregnant or nursing animals. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Interceptor and Sentinel are safe for Border Collies. It probably is the safest as it is aimed only at preventing heartworm. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Based on your recommendations, I will not use Vectra. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Unless youre, say, an expat living in China, you can definitely find a better option. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Id like to have a Smooth Collie in the future. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? ? Thank you for bringing this to my attention! That way if a tick does make it past the essential oil barrier and bite, itll die anyway. Their treatment for this was nexgard and medicated baths. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. Interceptor is the go-to heartworm preventive for many Collie parents. While my pain levels went down, I noticed that my heart rate went up! If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Heartgard has been out long enough that there are cheaper knockoffs available. is it safe or not to use it? Thank you for the useful information which is a little easier (clearer) to understand than most. Channel 2 Consumer Investigator Jim Strickland has obtained records showing dog owners believe the . Our are both indoors and outdoors. (There are other places, but none more affordable that Ive found.) Simparica offers safe and efficient monthly flea and tick protection. Whats the best safest flea tick treatment for a collie puppy? Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? Simparica is used to control flea and tick infestations in dogs. I didnt see the link for the drug compatibility. . If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. However, it did make my Collies too itchy. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. I have a female 3 year old collie. Happy to help! The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. Simparica is a flavored chewable solution for fast and effective treatment against fleas and ticks. The manufacturer of ProHeart has tested the product for safety in dogs with the MDR1 mutation. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. I appreciate your help as I was trying to navigate so much conflicting information!! Both spot ons and both effective in that neither of . The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). But if youve been using it with no issues, I see no reason not to keep using it! Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. (Of course, skin irritation can happen with any topical product.) We do eat it! I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Thank you thank you thank you for this article. Appreciated!!! No treatment-related clinical signs were observed. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. Sugar is almost 4 months old now! My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. Any thoughts on either of these? However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Given at the proper doses and under the supervision of a veterinarian, ivermectin is safe for most dogs and is very effective in treating and preventing a number of parasites. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. They said Frontline Plus doesnt really work anymore like it used too. What Can Cause Seizures in Dogs? Pet owners will have . Thats what I plan to use in future, when my oldest dog reaches that point. As a drug in the isoxazoline class, all Simparica products should be used with caution in dogs with a history of seizures, epilepsy, or neurologic disorders. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . Flea allergy dermatitis tends to occur mostly in the late summer. You might want to look at the information on Nexgard. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). I went back to using Frontline Plus for them. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. , Emily, thanks for a very helpful and informative article. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. Thank you for the reminder! Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. I used Interceptor last year with no issues. You can even scatter some on your dogs bed. Trish. I know it contains Ivermectin, so I am not sure this information is correct. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. Thanks for your informative article. Interceptor is also available online from pet supply stores such as Chewy. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. Thank you for your article. Im leaning toward Frontline Plus based on what you wrote. That indicates it is a strong chemical compound, so do watch for skin irritation. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into . Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. Im happy to hear it and so glad it helped! Please tell me which is the safest! I honestly didnt know they existed until I started researching more to answer your question. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. Dogs with the MDR1 mutation are not at increased risk for adverse effects. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. In some cases these can even lead to death. Is this vaccine something youve heard of? Congratulations and good luck with your new dog! The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 mutation. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. It just depends on the individual dog. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. (The Environmental Protection Agency is responsible for approving external flea and tick products.) That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Second, Id like to ask a question if you dont mind. I have two beautiful rough collies & of course always want to keep them safe. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. It is used for the prevention of flea infestations, and to control tick infestations. . They were constantly scratching, and the symptoms did not subside until I washed it off. There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. Use with caution in dogs with a history of seizures. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Thank you!! It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. This is where this can get tricky with the MDR1 gene mutation. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. No adverse effects were observed. WSU is the leader inidentifyingdrugs that may be dangerousfor dogs with the MDR1 mutationand can identifyalternative medications and doses. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Wow! Hi there , thank you for putting this information up! Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Natural Chemistry claims to kill on contact and to be safe for puppies. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Just want to do what is best for them? A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. My 2 Collies both had negative skin reactions to Advecta 3D, unfortunately. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Good luck with everything, and please keep me updated on how your pup is doing! Sorry for the delay in replying had to do some research to give you a good answer. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Congratulations on the new kitten. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. , Thanks for the reply! Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. I just quote the ones who are knowledgeable about MDR1. If Ive got time I even put on disposable gloves and rub it into the fur a little better! Happy to help! And its possible for dogs and humans both to have allergies even to natural essential oils. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Prior to administration of ProHeart 12, dogs should be tested for existing heartworm infections. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. If your dogs arent reacting to it, why are you switching? My dogs are on Sentinel right now and Frontline Gold. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Giardia can be passed to and cause diarrhea in humans. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange.

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